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Capillary Electroseparations
LGC has actively promoted capillary electrophoresis (CE) and its associated
techniques since 1995, and has invested in systems with diverse capability for R&D
and high throughput studies. The pharmaceuticals industry, in particular, has bought
in to the potential of capillary electroseparations, but LGC is also in the business
of proving wider applications. One of the first successful marriages of CE on-line
with electrospray ionisation mass spectrometry (ESI-MS) was brokered here in 1998,
providing a rapid, highly selective method for quantitation of the carbohydrate
additive gellan gum in complex food matrix materials [1]. Other successes to date
have included capillary electrochromatographic (CEC) analysis of mainstream and
sidestream tobacco smoke; quantitation of organic acids for the petrochemicals
industry; and a comparison of CE, CEC, micellar electrokinetic chromatography (MECC),
and liquid chromatography for determination of impurities in a proprietary drug.
Building on these successes LGC now offers a comprehensive Electroseperations Consultancy Service which can be tailored to meet the needs of it's customers.
Electroseperations Consultancy Service
Capillary Electrophoresis (CE) is an important modern chemicals separation technique that is growing in popularity within industrial analytical operations. CE provides high efficiency, short analysis time, low cost and is suitable for work on small sample volumes or in complex matrices. The technique is, however, very different in operation from the more familiar separation methods in chromatography, and specialist knowledge is required to develop optimised methods and validate these for routine use within a quality controlled environment. CE includes a large number of 'sub techniques' (modes) such as MEKC (Micellar Electrokinetic Chromatography), CEC (Capillary Electrochromatography), CGE (Capillary Gel Electrophoresis) and IEF (Isoelectric Focusing). The selection of the most appropriate mode is critical to developing robust methods.
LGC's Electroseparations Consultancy Team stands at the forefront of CE application, method development and validation. The Team has proven its scientific skills and quality service with a number of clients covering the Food, Environment, Forensic, Pharmaceutical and Bioscience sectors. Operating out of a purpose built laboratory the team offers method development, validation and routine analysis services using state-of-the-art instrumentation. Capabilities extend to all modes of CE and to sensitive UV, MS or fluorescence detection. In addition the Team offers at-site services (across Europe) in Training on Beckman (P/ACE and MDQ) and Agilent (HP3DCE) instruments, and in method development and validation. Client work is performed under strict confidentiality and to the appropriate quality standards.
Examples of work performed for clients are:
- Establishing protein profiles for a manufacturing food component
- Developing a robust method for measuring phenols in a company product
- Determining the acid composition of an industrial process stream
- Producing a reproducible protocol for specialist DNA applications
- Quantitation of a novel carbohydrate in complex food matrices
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