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TRMV43 - Method validation
30 November 2010, 3 days

Method validation is an essential part of establishing and ensuring the quality of analytical data. It cannot be guaranteed that data will be fit for purpose unless the performance of the test method has been studied and demonstrated to be adequate. Method validation is the process that provides evidence that a test method is capable of providing data that are suitable for a particular application. It is a requirement of the ISO/IEC 17025 laboratory accreditation standard and many other sectoral regulations and directives. Method validation should always be a planned activity. This course introduces the statistics required for interpreting validation data and provides the tools to plan and carry out effective validation studies.

What are the benefits?

This course will help you:

  • Understand method validation and its requirements
  • Select and apply the statistics required during method validation
  • Select and use the appropriate types of method validation studies
  • Appreciate and understand the link between method validation and measurement uncertainty

Contents

The course will cover:

Day 1 - Essential statistics

  • Introduction to statistics for method validation
  • Significance testing –t-tests and the F-test
  • Analysis of variance (ANOVA)
  • Linear regression

 

Day 2 - Providing the tools

  • Introduction to the concepts of method validation
  • Building a validation protocol
  • Performance parameters; precision, bias and ruggedness

 

Day 3 - Further tools

  • Performance parameters; selectivity, LoD, LoQ, linearity and working range
  • Using validation data to estimate measurement uncertainty
  • Impact of equipment qualification on method validation

 

Who should attend?

This course is designed for analytical chemists and potential or existing laboratory managers who are involved in method development and method validation.

Start date/time 30 November 9:00am
Duration 2 days
Cost £1250 + VAT
Location Teddington

schedule

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