News
02-Feb 2010 –
LGC Standards puts more
drug discovery tools in your
belt
A new Tools for ADME/Tox resource guide is now
available
LGC Standards has
launched a new absorbtion, distribution, metabolism and
excretion (ADME) toxicology guide comprising a unique
collection of labelled and unlabelled reagents and standards, as
well as important biological model systems.
The Tools for ADME/Tox guide provides
reference to Food and Drug Administration (FDA) guidelines and has
specifically been developed for preclinical drug discovery and
development scientists working across the spectrum of ADME and
toxicology preclinical drug discovery and research.
The guide’s quick reference tables provide
details of key metabolising enzymes with relevant substrates,
metabolites, inhibitors and inducers. These tables then link to an
alphabetical product listing which enable researchers to easily
locate the specific reference standards and reagents required for
their assays. The listing includes FDA Drug Development and Drug
interaction guidance listing substrates, inhibitors and inducers as
either preferred or acceptable. A significant number of metabolite
standards are also available both labelled and unlabelled, with
each product format’s availability clearly indicated.
The guide comprises a collection of model
systems commonly used in preclinical drug discovery research. The
range includes fresh hepatocytes from a series of species,
available the day after isolation and key immortalised cell lines
such as Caco-2 (HTB-37™) and primary cells from
ATCC®.
LGC Standards has developed strong
partnerships with many of the world’s leading standards and
reference material producers. These partnerships, combined with our
own recognised and accredited production capabilities, positions
LGC Standards as a key supplier to both research and quality
control laboratories across a diverse range of industries. LGC
Standards in partnership with ATCC has supplied biological cultures
and bio products to the European life science research community
for almost 10 years.
To obtain your copy of the new Tools for
ADME/Tox resource guide, please contact LGC Standards by email
at pharma@lgcstandards.com or telephone: +44 (0)20 8943 8480.
- Ends -
Notes to
editors:
About LGC
Standards
LGC Standards (http://www.lgcstandards.com/)
provides products and services to improve measurement and quality
control within the laboratory, and is part of LGC, whose Research
and Technology Division acts as the UK National Measurement
Institute for Chemical and Biochemical Measurements. LGC Standards
supplies over 20,000 reference materials, pharmaceutical impurity
reference standards, proficiency testing and training in analytical
quality. LGC Standards is headquartered in Teddington, Middlesex,
UK. Its global centre for excellence in proficiency testing is
located in Bury (Greater Manchester). LGC Standards has offices in
France, Germany, Italy, Poland, Spain, Sweden, China, Russia and
the UK, a joint venture presence in India, and representatives in
Bulgaria, Czech Republic, Finland, Hungary, Ireland, Romania,
Turkey and the US.