Science & innovation
Nanotechnology
Real- time cell measurements for nanoparticle safety
testing
Through validation of a label-free, real time, cell electronic
sensing system, LGC is able to measure changes in cell number
following nanoparticle exposure. This technique enables continual
analysis of the cells using electrical impedance measurements and
provides quantitative information about the rates and mechanisms of
toxicity which can be missed when using traditional assays.
This technology has enabled LGC to demonstrate reproducible
toxicity measurements in a range of cell lines using a panel of
nanoparticles with different chemical properties.
Unlike traditional toxicity assays, which were run as a direct
comparison, the cell electronic sensing system was shown not to be
susceptible to measurement interference by the nanoparticles
allowing the relationship between toxic response in the cells and
nanoparticle composition to be measured. Importantly, the real time
capability has enabled LGC scientists to uncover unique biological
responses that cells undergo immediately following nanoparticle
exposure; these responses are missed in traditional assays.
Validation of this technology opens up the real possibility of
developing standardised high throughput testing regimes for
nanotoxicity measurement.
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